The fluorine lined pneumatic diaphragm regulating valve is composed of a pneumatic multi spring diaphragm mechanism and a diaphragm valve with low flow resistance, a straight through single seat regulating mechanism, or a packing free structure that is simple and easy to maintain. A layer of anti-corrosion materials such as perfluoroethylene propylene (F46) and soluble polytetrafluoroethylene (PFA) are coated on the inner wall and valve core in contact with the fluid, which can completely cut off the contact between corrosive media and the valve body shell. This valve can withstand corrosive media such as acid, alkali, and salt, as well as working environments with strict leakage requirements. It is an ideal process automatic control product in chemical pipeline systems.